2-Bromonicotinaldehyde → 2-[4-[(2-Fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]pyridine-3-carbaldehyde
반응식
Br[C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[F:10][C:11]1[S:15][C:14]2[C:16]3([O:29][CH2:30][CH2:31][C:13]=2[CH:12]=1)[CH2:21][CH2:20][N:19]([CH2:22][C:23]1[C:24]([CH3:28])=[N:25][NH:26][CH:27]=1)[CH2:18][CH2:17]3>>[F:10][C:11]1[S:15][C:14]2[C:16]3([O:29][CH2:30][CH2:31][C:13]=2[CH:12]=1)[CH2:21][CH2:20][N:19]([CH2:22][C:23]1[C:24]([CH3:28])=[N:25][N:26]([C:2]2[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH:27]=1)[CH2:18][CH2:17]3참가 물질
3
실험 절차
The compound of Preparation 13 is essentially prepared as described in Preparation 12 by using 2-bromopyridine-3-carbaldehyde and 2-fluoro-1′-[(3-methyl-1H-pyrazol-4-yl)methyl]spiro[4,5-dihydrothieno[2,3-c]pyran-7,4′-piperidine]. Residue is purified by normal phase Isco chromatography to yield 83% of the title compound. MS (m/z): 427 (M+1).
후처리
- customThe compound of Preparation 13
- customis essentially prepared