Triethylamine → (2-Bromo-3-pyridyl)methyl methanesulfonate
반응식
C(N(CC)CC)C.[Br:8][C:9]1[C:14]([CH2:15][OH:16])=[CH:13][CH:12]=[CH:11][N:10]=1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[CH3:17][S:18]([O:16][CH2:15][C:14]1[C:9]([Br:8])=[N:10][CH:11]=[CH:12][CH:13]=1)(=[O:20])=[O:19]참가 물질
5
실험 절차
Triethylamine (8.90 mL) is added to a round bottom flask containing a solution of (2-bromopyridin-3-yl)methanol (8 g, 42.55 mmol) in dichloromethane (212 mL) at 0° C., then methanesulfonyl chloride (3.95 mL) is added and the mixture is stirred at that temperature for 1.5 h. After that time the mixture is washed with water and organic layer is decanted, dried over magnesium sulfate and solvent evaporated under reduced pressure to yield 10.4 g of the title compound used without further purification. MS (m/z): 266, 268 (M+1; M+3).
후처리
- washAfter that time the mixture is washed with water and organic layer
- customis decanted
- dry with materialdried over magnesium sulfate and solvent
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-593bcd02dce941f9b453c909b64faf74
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08232289B2
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