Ethanol → 2-(2-Bromopyridin-3-yl)acetonitrile

HRID 1517581노트

반응식

HRID 1517581 반응식
[Br:1][C:2]1[C:7]([CH2:8]Br)=[CH:6][CH:5]=[CH:4][N:3]=1.[C-:10]#[N:11].[Na+].O.C(O)C>ClCCl>[Br:1][C:2]1[C:7]([CH2:8][C:10]#[N:11])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 962WaterHCID 8929Sodium CyanideHCID 109010782-Bromo-3-(bromomethyl)pyridine

생성물 1

HCID 534035092-(2-Bromopyridin-3-yl)acetonitrile수율 83%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 2-bromo-3-bromomethyl-pyridine (840 mg, 3.35 mmol) and sodium cyanide (187.99 mg, 3.68 mmol) is stirred and refluxed for 1 h in a mixture water (10 mL)-ethanol (2 mL). The reaction mixture is diluted with dichloromethane and washed with saturated aqueous solution of sodium bicarbonate. The organic layer is separated, dried over magnesium sulfate and the solvent evaporated in vacuo to give 83% of the title compound that is used without further purification. MS (m/z): 197 (M+1), 199 (M+3).

후처리

  1. washwashed with saturated aqueous solution of sodium bicarbonate
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulfate
  4. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-259963ad65984f20a3e2916a844a5af0
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232289B2

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