Triethylamine → HCID 69453076, 화합물

HRID 1517633노트

반응식

HRID 1517633 반응식
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C@H:10]([NH:14][C:15]([NH:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=1[CH:20]=[N:21][N:22]3[C:27]([O:29][CH2:30][P:31](=[O:34])([OH:33])[OH:32])=[O:28])=[O:16])[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].[CH2:35]([N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH3:36]>CO>[CH2:35]([N:37]([CH2:40][CH3:41])[CH2:38][CH3:39])[CH3:36].[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C@H:10]([NH:14][C:15]([NH:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=1[CH:20]=[N:21][N:22]3[C:27]([O:29][CH2:30][P:31](=[O:32])([OH:34])[OH:33])=[O:28])=[O:16])[CH2:9][CH2:8]2)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 16226508HCID 16226508, 화합물

생성물 1

HCID 69453076HCID 69453076, 화합물수율 100.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Suspended 50.2 mg (103 μmol) of compound from Example 21D in 10 mL methanol, added 10.4 mg (103 μmol) triethylamine, stirred the colorless solution for 10 minutes at ambient temperature, concentrated and vacuum dried. Obtained 61 mg (100% yield) of the title compound as an off-white powder. 1H NMR (methanol-d4) δ: 1.29 (t, 9H), 1.32 (s, 9H), 1.90 (m, 1H), 2.59 (m, 1H), 2.89 (m, 1H), 3.00 (m, 1H), 3.16 (q, 6H), 4.54 (d, 2H), 5.29 (t, 1H), 7.28 (s, 2H), 7.31 (s, 1H), 7.52 (t, 1H), 7.74 (d, 1H), 7.97 (d, 1H), 8.36 (s, 1H). Anal Calcd for C23H27N4O6P.1.0 triethylamine.0.7 methanol: C, 58.47; H, 7.40; N, 11.48. Found: C, 58.46; H, 7.38; N, 11.44.

후처리

  1. concentrationconcentrated
  2. customvacuum dried

출처 및 근거

ORD 기록
ord-97fafbc949604f82bbb64d782a995058
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232309B2

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