Potassium Hydroxide → N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

HRID 1517876노트

반응식

HRID 1517876 반응식
C([O:4][C:5]1([CH2:8][O:9][C:10]2[CH:19]=[C:18]3[C:13]([C:14]([O:20][C:21]4[CH:26]=[CH:25][C:24]([NH:27][C:28]([C:30]5[C:31](=[O:43])[N:32]([C:37]6[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=6)[N:33]([CH3:36])[C:34]=5[CH3:35])=[O:29])=[CH:23][C:22]=4[F:44])=[CH:15][CH:16]=[N:17]3)=[CH:12][CH:11]=2)[CH2:7][CH2:6]1)(=O)C.[OH-].[K+]>CO>[F:44][C:22]1[CH:23]=[C:24]([NH:27][C:28]([C:30]2[C:31](=[O:43])[N:32]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[N:33]([CH3:36])[C:34]=2[CH3:35])=[O:29])[CH:25]=[CH:26][C:21]=1[O:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([O:9][CH2:8][C:5]3([OH:4])[CH2:6][CH2:7]3)=[CH:11][CH:12]=2)[N:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 66684940HCID 66684940, 화합물

생성물 1

HCID 66670625N-(3-fluoro-4-(7-((1-hydroxycyclopropyl)methoxy)quinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide수율 100.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of compounds 1-((4-(4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)quinolin-7-yloxy)methyl)cyclopropyl acetate (110 mg, 0.18 mmol) in 8 mL of methanol was added KOH (100 mg, 1.78 mmol) slowly. After stirring at rt for 0.5 hr, the reaction mixture was filtered and the solid was washed with ethyl acetate (10 mL×2) to give the title compound as a white solid (100 mg, 29%).

후처리

  1. filtrationthe reaction mixture was filtered
  2. washthe solid was washed with ethyl acetate (10 mL×2)

출처 및 근거

ORD 기록
ord-00fd4e165355417eae1104d3a58a8bba
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232294B2

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