Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Bis(trifluoromethyl)benzaldehyde → 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Bis(trifluoromethyl)benzaldehyde | HCID 136247 | — |
| 반응물 | 1-methyl-1H-tetrazol-5-amine | HCID 138492 | — |
| 반응물 | 2-methyl-2H-1,2,3,4-tetrazol-5-amine | HCID 138677 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine | HCID 76645725 | — |
반응 단계
A crude mixture of 5-amino-2-methyltetrazole and 5-amino-1-methyltetrazole is treated with 3,5-bis(trifluoromethyl)benzaldehyde (48 mL, 71 g, 0.29 mol) in toluene (780 mL), and the mixture is stirred and refluxed for 5 hours. The resulting mixture is filtered to remove off the insoluble solid (5-amino-1-methyltetrazole), and the residue is washed with hot toluene. The filtrate is concentrated to give crude 2-methyl-N-[3,5-bis(trifluoromethyl)phenylmethylene]-2H-tetrazole-5-amine (70.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08232403B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-0ecfce2fee11470d9d89f56af0ea6374 |
| 출처 메모 | uspto-grants-2012_07 |