4-Bromo-2-methyl-6-nitroaniline → 2'-Fluoro-5-methyl-biphenyl-3,4-diamine

반응식

Br[C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH2:11])=[C:4]([CH3:12])[CH:3]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B1OC(C)(C)C(C)(C)O1>>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([NH2:11])=[C:6]([NH2:8])[CH:7]=1

참가 물질

반응물 2

HCID 5226794-Bromo-2-methyl-6-nitroaniline

HCID 121597222-(2-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

생성물 1

HCID 592801102'-Fluoro-5-methyl-biphenyl-3,4-diamine

실험 절차

The title compound was prepared from 4-bromo-2-methyl-6-nitro-phenylamine and 2-(2-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane using the procedures described in Example 1, steps D and E. 1H-NMR (400 MHz, CDCl3) δ: 7.36 (td, J=7.8, 1.9 Hz, 1H), 7.16-7.23 (m, 1H), 7.03-7.15 (m, 2H), 6.84 (s, 1H), 6.79-6.82 (m, 1H), 3.47 (br. s., 4H), 2.20 (s, 3H).

출처 및 근거

ORD 기록: ord-3df858fd05e64266b4e74258b4fc0147
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08232409B2

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