Imidazole → HCID 67346559, 화합물

HRID 1518247노트

반응식

HRID 1518247 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][OH:11].N1C=CN=C1.[CH:17]([Si:20](Cl)([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])([CH3:19])[CH3:18]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][O:11][Si:20]([CH:24]([CH3:26])[CH3:25])([CH:21]([CH3:23])[CH3:22])[CH:17]([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 139400Triisopropylsilyl chlorideHCID 10867706(2-Bromo-5-methoxyphenyl)methanol

생성물 1

HCID 67346559HCID 67346559, 화합물수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

(2-Bromo-5-methoxyphenyl)methanol (1 eq.) was dissolved in anhydrous DMF (1.1M solution) and imidazole (1.05 eq.) was added. To the stirred solution triisopropylsilyl chloride (1.1 eq.) was added and the resulting mixture was left stirring at RT for 8 h. All volatiles were evaporated in vacuo and the residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel. After evaporation in vacuo the product was obtained as a colorless oil (94%), which was used without further characterization in the next reaction.

후처리

  1. waitthe resulting mixture was left
  2. customAll volatiles were evaporated in vacuo
  3. filtrationthe residual material was filtered with PE/EtOAc (9:1) over a pad of silica gel
  4. customAfter evaporation in vacuo the product

출처 및 근거

ORD 기록
ord-46649b618eff41dc8a2be2d8f73d2e6b
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232390B2

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