Trifluoroacetic acid → tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(1-methylpiperidin-4-ylamino)phenoxy)propyl)picolinate

HRID 1518398

반응식

HRID 1518398 반응식
C(O)(C(F)(F)F)=O.S1C2C=CC=CC=2N=C1NC(C1C=CC=C2C=1CN(C1SC(CCCI)=C(C(OCC)=O)N=1)CC2)=O.[CH3:44][N:45]1[CH2:50][CH2:49][CH:48]([NH:51][C:52]2[CH:57]=[CH:56][C:55]([OH:58])=[CH:54][CH:53]=2)[CH2:47][CH2:46]1.[S:59]1[C:63]2[CH:64]=[CH:65][CH:66]=[CH:67][C:62]=2[N:61]=[C:60]1[NH:68][C:69]([C:71]1[CH:72]=[CH:73][CH:74]=[C:75]2[C:80]=1[CH2:79][N:78]([C:81]1[N:86]=[C:85]([C:87]([O:89][C:90]([CH3:93])([CH3:92])[CH3:91])=[O:88])[C:84]([CH2:94][CH2:95][CH2:96]I)=[CH:83][CH:82]=1)[CH2:77][CH2:76]2)=[O:70]>>[S:59]1[C:63]2[CH:64]=[CH:65][CH:66]=[CH:67][C:62]=2[N:61]=[C:60]1[NH:68][C:69]([C:71]1[CH:72]=[CH:73][CH:74]=[C:75]2[C:80]=1[CH2:79][N:78]([C:81]1[N:86]=[C:85]([C:87]([O:89][C:90]([CH3:92])([CH3:91])[CH3:93])=[O:88])[C:84]([CH2:94][CH2:95][CH2:96][O:58][C:55]3[CH:56]=[CH:57][C:52]([NH:51][CH:48]4[CH2:47][CH2:46][N:45]([CH3:44])[CH2:50][CH2:49]4)=[CH:53][CH:54]=3)=[CH:83][CH:82]=1)[CH2:77][CH2:76]2)=[O:70]

참가 물질

5

반응물 4

HCID 6422Trifluoroacetic acidHCID 437426714-(1-Methylpiperidin-4-ylamino)phenolHCID 59447467ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-iodopropyl)thiazole-4-carboxylateHCID 59447593tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-iodopropyl)picolinate

생성물 1

HCID 59447558tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(1-methylpiperidin-4-ylamino)phenoxy)propyl)picolinate

실험 절차

The compound 104B was prepared as a TFA salt in a similar manner to the synthesis of step 2 of Example 51 by substituting compound 51A and compound 2C with compound 104A and compound 96D, respectively: APCI (+)/LC/MS: 733 (M+H)−.

출처 및 근거

ORD 기록
ord-58be109a047940fcb43103287f37d318
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232273B2

연결된 노트

불러오는 중…