Potassium Carbonate → 6-Ethynylnaphthalen-2-ol

HRID 1518405

반응식

HRID 1518405 반응식
C[Si]([C:5]#[C:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)(C)C.C([O-])([O-])=O.[K+].[K+]>CO.C1COCC1.C(OCC)(=O)C>[C:6]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([OH:17])[CH:11]=[CH:10]2)#[CH:5]

참가 물질

6

반응물 2

HCID 11430Potassium CarbonateHCID 594475526-((Trimethylsilyl)ethynyl)naphthalen-2-ol

생성물 1

HCID 190817686-Ethynylnaphthalen-2-ol

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

Compound 110A (770 mg, 3.20 mmol) in MeOH (5 ml) and THF (10 ml) was treated with K2CO3 (885 mg, 6.41 mmol) at room temperature for 3 h. The reaction was diluted with ethyl acetate and washed with water. The organic layer was concentrated and the residue was purified by flash chromatography, eluted with DCM to provide the compound 110B.

후처리

  1. washwashed with water
  2. concentrationThe organic layer was concentrated
  3. customthe residue was purified by flash chromatography
  4. washeluted with DCM

출처 및 근거

ORD 기록
ord-b26daf207e0a4777895a4cc24c021b56
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232273B2

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