Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → 2-Hydroxybicyclo[3.2.0]heptan-6-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 6,6-Diethoxybicyclo[3.2.0]heptan-2-one | HCID 12564365 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 용매 | Monobasic potassium phosphate | HCID 516951 | — |
| 생성물 | 2-Hydroxybicyclo[3.2.0]heptan-6-one | HCID 13443807 | — |
반응 단계
To a stirred solution of compound 1F in dioxane (50 mL) and 2M KH2PO4 (50 mL) was added NaBH4 (1.0 g, 26.4 mmol) over a 10 min-period, and the stirring was continued at RT for 1 hr. The reaction mixture was diluted with 2M HCl to adjust pH to 1, and stirred at RT for another 1 hr. The reaction was concentrated, dissolved in EtOAc, washed with water, dried over Na2SO4, and concentrated. Purification by silica gel chromatography (50% EtOAc in hexanes) provided the title compound (1.9 g) as a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732480B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-479eea0990784411930dc1e50887c603 |
| 출처 메모 | uspto-grants-2010_06 |