Oxalyl chloride → 5-Bromo-2-chloro-3-pyridinecarbonyl chloride
반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl.CN(C)C=O>[Br:1][C:2]1[CH:10]=[C:6]([C:7]([Cl:15])=[O:8])[C:5]([Cl:11])=[N:4][CH:3]=1참가 물질
5
실험 절차
To a slurry of 5-bromo-2-chloronicotinic acid (2.063 g, 8.725 mmol) in methylene chloride (20 mL) was slowly added oxalyl chloride (1.11 g, 8.725 mmol) followed by the addition of dimethylformamide (5 drops). After 4H the mixture was concentrated in vacuo to provide 2.21 g of 5-bromo-2-chloropyridine-3-carbonyl chloride as a light brown solid, which was used as is in the next reaction.
후처리
- concentrationAfter 4H the mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-6c60691e92624cf885feaaa13f5d2984
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08232406B2
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