4-Methoxy-3-methylbenzoic Acid → (r/s)-4-Methoxy-n-(5-methoxy-2,3-dihydro-1h-inden-1-yl)-3-methylbenzamide

반응식

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1[CH3:12].[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[CH:20]([NH2:24])[CH2:19][CH2:18]2>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:24][CH:20]2[C:21]3[C:17](=[CH:16][C:15]([O:14][CH3:13])=[CH:23][CH:22]=3)[CH2:18][CH2:19]2)=[O:9])=[CH:5][C:4]=1[CH3:12]

참가 물질

반응물 2

HCID 27595834-Methoxy-3-methylbenzoic Acid

HCID 30167405-methoxy-2,3-dihydro-1H-inden-1-amine

생성물 1

HCID 57953985(r/s)-4-Methoxy-n-(5-methoxy-2,3-dihydro-1h-inden-1-yl)-3-methylbenzamide

실험 절차

Prepared in a similar manner to example 4 using 4-methoxy-3-methylbenzoic acid and 5-methoxy-2,3-dihydro-1H-inden-1-amine (Example 121-2a)(47%). MS (M+Hs 312).

출처 및 근거

ORD 기록: ord-49c629a992714aed9780acbfb44cb4cc
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09072313B2

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