Boron tribromide → 3-Nitro-4-phenylphenol

HRID 1518634노트

반응식

HRID 1518634 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:5]([N+:15]([O-:17])=[O:16])[CH:4]=1.B(Br)(Br)Br>ClCCl>[N+:15]([C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([O-:17])=[O:16]

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 114019374-Methoxy-2-nitro-biphenyl

생성물 1

HCID 121698073-Nitro-4-phenylphenol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

후처리

  1. additionwas added, under ice-water cooling
  2. additionthe reaction mixture was poured onto ice
  3. customthe reaction
  4. extractionextracted with ethyl acetate
  5. washThe organic layer was washed with a saturated aqueous solution of sodium chloride
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f1b6d565811542948de0849710533e13
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09072734B2

반응 노트

불러오는 중…