참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | 2-Chloro-4-(hydroxymethyl)-3-methylbenzonitrile | HCID 68577571 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Bromomethyl)-2-chloro-3-methylbenzonitrile | HCID 68577413 | 28.3% |
반응 단계
To a solution of compound 7B (700 mg, 3.9 mmol) in CH2Cl2 (15 mL) was added PBr3 (5.8 mL, 5.8 mmol, 1N in CH2Cl2) at −15° C., and stirred at −15° C. for 3 hr. The reaction was slowly quenched with saturated NaHCO3 solution at −15° C. The organic layer was separated, dried over MgSO4, and concentrated. Purification by silica gel chromatography (0-10% EtOAc in hexanes) provide the title compound (270 mg) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732480B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-a53eda7a21c6493b8351a35a680eae0b |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
