Acetyl chloride → 4-Aminotricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid--hydrogen chloride (1/1)

HRID 1519070노트

반응식

HRID 1519070 반응식
C([Cl:4])(C)=O.[NH2:5][CH:6]1[CH:13]2[CH2:14][C:9]3([C:16]([OH:18])=[O:17])[CH2:10][CH:11]([CH2:15][CH:7]1[CH2:8]3)[CH2:12]2>CO>[ClH:4].[NH2:5][CH:6]1[CH:13]2[CH2:14][C:9]3([C:16]([OH:18])=[O:17])[CH2:10][CH:11]([CH2:15][CH:7]1[CH2:8]3)[CH2:12]2

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 210997894-Aminotricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid

생성물 1

HCID 675491034-Aminotricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid--hydrogen chloride (1/1)수율 86.1%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
45 °C

실험 절차

At 0° C., in a 250-mL flask, MeOH (85 ml) was added with AcCl (16.08 g, 204.85 mmol), and then at room temperature, 4-amino-adamantane-1-carboxylic acid (8.0 g, 40.97 mmol) was added thereto. At 45° C., the mixture was stirred for 12 hours. After the reaction was completed, the solid was filtered by acetonitrile to obtain 4-amino-adamantane-1-carboxylate hydrochloride (8.17 g, 81%).

후처리

  1. filtrationthe solid was filtered by acetonitrile

출처 및 근거

ORD 기록
ord-bfe53dec20c841b79a2b92edfbbaa345
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073830B2

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