Acetaldehyde → 2-Ethylcyclohexane-1,3-dione

HRID 1519401노트

반응식

HRID 1519401 반응식
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[CH3:9][CH:10]=O.CCOC(C1CC(C(OCC)=O)=C(C)NC=1C)=O.N1C=CC=CC=1>CO.C(Cl)Cl>[CH2:9]([CH:2]1[C:3](=[O:7])[CH2:4][CH2:5][CH2:6][C:1]1=[O:8])[CH3:10]

참가 물질

7

반응물 4

HCID 177AcetaldehydeHCID 1049PyridineHCID 104341,3-CyclohexanedioneHCID 70849Hantzsch ester

생성물 1

HCID 108988052-Ethylcyclohexane-1,3-dione수율 69%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

1,3-Cyclohexanedione (10 g, 89.2 mmol), 40% aqueous CH3CHO (49.4 g, 445.9 mmol) were dissolved in methanol (40 mL) followed by addition of Hantzsch ester (22.7 g, 89.2 mmol) and pyridine (2.1 g, 18.74 mmol) under nitrogen. The resulting light yellow mixture was stirred at room temperature overnight, then concentrated to give crude product that was re-slurried in a mixture of CH2Cl2 (40 mL) and hexanes (60 mL) to furnish 2-ethyl-1,3-cyclohexanedione (8.6 g, 69%).

후처리

  1. concentrationconcentrated
  2. customto give crude product that

출처 및 근거

ORD 기록
ord-0be1b85333fe4f2e857f2598abcd2658
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073888B2

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