Trifluoroacetic acid → 7-Benzothiazoleacetic acid

반응식

Br[C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:11]([OH:17])([C:13](F)(F)F)=[O:12]>>[S:9]1[C:10]2[C:2]([CH2:13][C:11]([OH:17])=[O:12])=[CH:3][CH:4]=[CH:5][C:6]=2[N:7]=[CH:8]1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 115213507-Bromobenzothiazole

생성물 1

HCID 687568187-Benzothiazoleacetic acid

실험 절차

The title compound (20 mg) was prepared from 7-bromobenzo[d]thiazole according to protocol P. LCMS (0.05% TFA): [M+1]+ 194.1. 1H-NMR (CDCl3, 400MHz): δ9.05 (s, 1H), 8.10(d, 1H, J=6.8Hz), 7.53 (m, 1H), 7.39 (d, 1H, J=6.8Hz), 3.96(s, 2H).

출처 및 근거

ORD 기록: ord-aa41acc0cffc42a0b18540771aebc5bb
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09073891B2

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