Acetamidine monohydrochloride → HCID 178434591, 화합물

HRID 1519767노트

반응식

HRID 1519767 반응식
Cl.[C:2](=N)([NH2:4])[CH3:3].[NH:6]([C:8]([C:10]1[C:14]([CH3:15])=[CH:13][S:12][C:11]=1[NH:16][C:17](=[O:30])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:29])=O)[NH2:7]>>[CH3:15][C:14]1[C:10]([C:8]2[NH:6][N:7]=[C:2]([CH3:3])[N:4]=2)=[C:11]([NH:16][C:17](=[O:30])[CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][CH2:21][C:20]2=[O:29])[S:12][CH:13]=1

참가 물질

3

반응물 2

HCID 67170Acetamidine monohydrochlorideHCID 68755429N-(3-(hydrazinecarbonyl)-4-methylthiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide

생성물 1

HCID 178434591HCID 178434591, 화합물

실험 절차

The title compound was prepared from acetimidamide hydrochloride (55 mg, 0.590 mmol) and N-(3-(hydrazinecarbonyl)-4-methylthiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide (141 mg, 0.393 mmol) according to the procedure of Example 1.11.2, above. Retention time (min)=4.106, method [7], MS(ESI) 382.1 (M+H); 1H NMR (300 MHz, CDCl3) δ 12.07 (s, 1H), 7.23-7.31 (m, 2H), 7.05-7.23 (m, 2H), 6.57 (s, 1H), 4.86 (s, 2H), 3.02-3.07 (m, 2H), 2.84-2.87 (m, 2H), 2.41 (s, 3H), 2.39 (s, 3H).

출처 및 근거

ORD 기록
ord-560ff6660fde48799b8699df1b982792
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073891B2

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