tert-Butyl bromoacetate → Acetate

HRID 1519846노트

반응식

HRID 1519846 반응식
[F:1][C:2]1([F:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].Br[CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]>>[F:12][C:2]1([F:1])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C:3]1=[O:11].[C:15]([O-:17])(=[O:16])[CH3:14]

참가 물질

4

반응물 2

HCID 79177tert-Butyl bromoacetateHCID 53238213,3-Difluoroindolin-2-one

생성물 2

HCID 175AcetateHCID 68754561tert-Butyl 2-(3,3-difluoro-2-oxoindolin-1-yl)acetate

실험 절차

The title compound was prepared from 3,3-difluoroindolin-2-one using protocol K except using tert-butyl 2-bromoacetate to give crude tert-butyl difluoro-2-oxoindolin-1-yl)acetate as a yellow oil. LCMS method [1] showed an M+Na peak of 306.1 with a retention time of 2.502 min.

출처 및 근거

ORD 기록
ord-4f21430a4b1c43b797dcf5eee51d1d81
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073891B2

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