Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Monobenzone → (S)-Glycidyl-4-benzyloxyphenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Monobenzone | HCID 7638 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | (S)-Glycidyl-4-benzyloxyphenol | HCID 54047008 | — |
반응 단계
A mixture of 4-benzyloxyphenol (2.0 g, 10 mMol) and potassium carbonate (4.14 g, 30 mMol) in acetone (50 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (2.23 g, 10 mMol) was added and the reaction mixture was heated under reflux for 18 hours. After cooling, the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726165 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-f128083fd7554ead9f40eeecd8845c28 |
| 출처 메모 | uspto-grants-1998_03 |