Triethylamine → HCID 86695474, 화합물
반응식
Cl.Cl.[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([NH2:13])[CH2:12][CH2:11]2)=[N:8][CH:9]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2([NH:13][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:11][CH2:12]2)=[N:8][CH:9]=1참가 물질
5
실험 절차
Commercially available 1-(5-bromopyridin-2-yl)cyclopropanamine dihydrochloric acid salt (494 mg, 1.73 mmol) is dissolved in CH2Cl2 (11.5 mL, 0.15M) and had 3.1 eq. of triethylamine (543 mg, 5.36 mmol) added to it. 1.1 eq. of methanesulfonyl chloride (218 mg, 1.9 mmol) is then added and the mixture stirred for 16 hours. Dichloromethane (20 mL) is added and washed with NaHCO3 (sat, aq). The solvent is evaporated to give the title compound (310 mg): m/z (Cl) 293 [M+H].
후처리
- additionadded to it
- washwashed with NaHCO3 (sat, aq)
- customThe solvent is evaporated
출처 및 근거
- ORD 기록
- ord-c904a191ed504546bf07709161c43428
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09073894B2
반응 노트
불러오는 중…