Oxalyl chloride → 3,3-Difluorocyclobutanecarbonyl chloride

HRID 1520861노트

반응식

HRID 1520861 반응식
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

생성물 1

HCID 838550033,3-Difluorocyclobutanecarbonyl chloride수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

후처리

  1. concentrationbefore concentrating in vacuo

출처 및 근거

ORD 기록
ord-f895a7f56e714d33a19ab2dcff52f8cb
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073871B2

반응 노트

불러오는 중…