참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tricyclohexylphosphine | HCID 75806 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 반응물 | 3-Bromo-5-(2-methoxypropan-2-yl)pyridine | HCID 66788134 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (5-(2-Methoxypropan-2-yl)pyridin-3-yl)boronic acid | HCID 89156274 | — |
반응 단계
To a vial containing the title compound from Example 49 Step A (0.07 g, 0.30 mmol), bis(pinacolato)diboron (0.093 g, 0.37 mmol), potassium acetate (0.090 g, 0.91 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.028 g, 0.030 mmol) and tricyclohexylphosphine (0.017 g, 0.061 mmol) was added 1,4-dioxane (3.0 mL). The vial was flushed with nitrogen, sealed tightly and heated to 80° C. overnight. The reaction was then concentrated under reduced pressure to provide the title compound which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09073929B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_07 |
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| ORD ID | ord-53d577ebc0b048af98fed108d0035ac2 |
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| 출처 메모 | uspto-grants-2015_07 |
|---|
