N-Bromosuccinamide → 6-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one

HRID 1521658노트

반응식

HRID 1521658 반응식
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2.[Br:13]NC(=O)CCC(N)=O>CN(C)C=O>[Br:13][C:11]1[C:2]([F:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:12])[CH2:5][CH2:4]2

참가 물질

4

반응물 2

HCID 9834204N-BromosuccinamideHCID 227369425-Fluoro-3,4-dihydroquinolin-2(1H)-one

생성물 1

HCID 709801486-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 5-fluoro-3,4-dihydroquinolin-2(1H)-one (146-4; 0.45 g, 0.00272 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinamide (0.53 g, 0.0029 mol). Reaction mass was allowed to stir for overnight. Ice cold water was added to reaction mass. The solid separated was filtered and dried thoroughly to obtain the title compound. MS (M+1): 246.0.

후처리

  1. customReaction mass
  2. additionIce cold water was added to reaction mass
  3. customThe solid separated
  4. filtrationwas filtered
  5. customdried thoroughly

출처 및 근거

ORD 기록
ord-80f57e261f5a44dcac8d28ddc0847a22
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073929B2

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