Ammonium Chloride → HCID 10797271, 화합물

HRID 1521748노트

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HRID 1521748 반응식
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([N+:11]([O-])=O)=[CH:4][CH:3]=1.[Cl-].[NH4+]>C(O)C.O.CCOC(C)=O.[Fe]>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH3:10])[C:5]([NH2:11])=[CH:4][CH:3]=1

참가 물질

7

반응물 2

HCID 25517Ammonium ChlorideHCID 107267696-Chloro-N-ethyl-3-nitropyridin-2-amine

생성물 1

HCID 10797271HCID 10797271, 화합물수율 100%

시약·촉매·용매 4

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
140 °C

실험 절차

To a solution of 6-chloro-N-ethyl-3-nitropyridin-2-amine (1.82 g, 9.04 mmol) in ethanol (20 mL) is added iron powder (2.52 g, 45.2 mmol) and a solution of ammonium chloride (2.42 g, 45.2 mmol) in H2O (8 mL). The mixture is heated in a microwave reactor at 140° C. for 30 min. The mixture is diluted with EtOAc, filtered and evaporated to afford the title compound as a brown oil (1.55 g, 100%) which was used in the next step without purification.

후처리

  1. filtrationfiltered
  2. customevaporated

출처 및 근거

ORD 기록
ord-1d5c5ed27ac343f0bc761c4559f73eb7
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073926B2

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