1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one → 3-Hydroxy-3-(2-(6-methoxypyridin-2-yl)-2-oxoethyl)-5-methyl-1-propylindolin-2-one

반응식

C(N1C2C(=CC=CC=2)C(O)(CC(=O)C2C=CC=CN=2)C1=O)CCC.[CH3:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([CH2:35][CH2:36][CH3:37])[C:30](=[O:38])[C:29]2=[O:39].[CH3:40][O:41][C:42]1[N:47]=[C:46]([C:48](=[O:50])[CH3:49])[CH:45]=[CH:44][CH:43]=1>>[OH:39][C:29]1([CH2:49][C:48]([C:46]2[CH:45]=[CH:44][CH:43]=[C:42]([O:41][CH3:40])[N:47]=2)=[O:50])[C:28]2[C:32](=[CH:33][CH:34]=[C:26]([CH3:25])[CH:27]=2)[N:31]([CH2:35][CH2:36][CH3:37])[C:30]1=[O:38]

참가 물질

반응물 3

HCID 29441601-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one

HCID 3125288Sbb038754

HCID 136420861-(6-Methoxypyridin-2-yl)ethan-1-one

생성물 1

HCID 863008263-Hydroxy-3-(2-(6-methoxypyridin-2-yl)-2-oxoethyl)-5-methyl-1-propylindolin-2-one

실험 절차

This compound was made in a similar manner to 1-butyl-3-hydroxy-3-(2-oxo-2-(pyridin-2-yl)ethyl)indolin-2-one using 5-methyl-1-propylindoline-2,3-dione and 1-(6-methoxypyridin-2-yl)ethanone (commercially available from Fisher Scientific). 1H-NMR δ 7.74 (m, 2H), 7.19 (s, 1H), 7.11 (d, 1H), 6.98 (d, 1H), 6.77 (d, 1H), 5.27 (bs, 1H), 4.03 (s, 3H), 3.65 (m, 3H), 3.49 (d, 1H), 2.30 (s, 3H), 1.74 (m, 2H), 0.97 (t, 3H).