(S)-(+)-N-(2,3-Epoxypropyl)phthalimide → 2-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]isoindole-1,3-dione

참여 물질

역할	이름	HCID	투입량
반응물	(S)-(+)-N-(2,3-Epoxypropyl)phthalimide	HCID 719412	—
반응물	Magnesium Chloride	HCID 5360315	—
반응물	4-(4-Isocyanatophenyl)morpholin-3-one	HCID 53341421	—
용매	Isoamyl Acetate	HCID 31276	—
생성물	2-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]isoindole-1,3-dione	HCID 11690317	95.5%

반응 조건

온도	120 °C

반응 단계

(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.56 g, 22.46 mmol, 1.3 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in isoamyl acetate (70 mL) respectively, and heated to 120° C. Then magnesium chloride (0.12 g, 1.28 mmol) was added, the mixture was reacted for 4 h, white solid was obtained by filtration (6.97 g, yield: 95.5%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09079892B2
출처 데이터셋	uspto-grants-2015_07
ORD ID	ord-0b9f202109ab4ef4a6965f916852ec03
출처 메모	uspto-grants-2015_07