Dimethylformamide → 1-Cyclopropylpiperidine-4-carbonyl chloride

HRID 1523719

반응식

HRID 1523719 반응식
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]([OH:12])=O)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:21])=O>ClCCl>[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([C:10]([Cl:21])=[O:12])[CH2:6][CH2:5]2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 162440131-CYCLOPROPylpiPERIDINE-4-CARBOXYLIC ACID

생성물 1

HCID 867249091-Cyclopropylpiperidine-4-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a stirred mixture of 1-cyclopropyl piperidine-4-carboxylic acid (10.0 grams, 48.6 mmol, obtained in above step) in dichloromethane (198 mL) cooled at 0° C. was added dry dimethyl formamide (2 mL) followed by drop wise addition of oxalyl chloride (12.5 mL, 145.8 mmol). The reaction mixture was gradually warmed to room temperature and stirred for 1 hour. The volatiles were removed under reduced pressure and the crude 1-cyclopropyl piperidine-4-carbonyl chloride (11.0 grams). This crude product was used in the next reaction without purification.

후처리

  1. temperatureThe reaction mixture was gradually warmed to room temperature
  2. customThe volatiles were removed under reduced pressure
  3. customThis crude product was used in the next reaction without purification

출처 및 근거

ORD 기록
ord-bbe0d73af82945a4809fddec6b1d506f
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079894B2

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