(4-Chloro-2-fluorophenyl)boronic acid → 7-(4-Chloro-2-fluorophenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

반응식

Br[C:2]1[CH:11]=[N:10][C:9]2[NH:8][CH2:7][CH2:6][O:5][C:4]=2[CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[C:15]([F:22])[CH:14]=1>>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[CH:11]=[N:10][C:9]3[NH:8][CH2:7][CH2:6][O:5][C:4]=3[CH:3]=2)=[C:15]([F:22])[CH:14]=1

참가 물질

반응물 2

HCID 4193595(4-Chloro-2-fluorophenyl)boronic acid

HCID 242296357-Bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

생성물 1

HCID 903128687-(4-Chloro-2-fluorophenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

실험 절차

Prepared in a manner similar to that found in Example 1 using of 7-bromo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine with (4-chloro-2-fluorophenyl)boronic acid. 1H NMR (400 MHz, CDCl3) δ 7.84 (m, 1H), 7.35-7.28 (m, 1H), 7.20-7.14 (m, 3H), 4.29-4.25 (m, 2H), 3.64-3.58 (m, 2H).

후처리

customPrepared in a manner similar to

출처 및 근거

ORD 기록: ord-68a452c0644f4ab7aaf70da2e63c0172
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09079866B2

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