Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione

HRID 1524250노트

반응식

HRID 1524250 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]

참가 물질

4

반응물 2

HCID 10935MaleimideHCID 119785-Methylindole

생성물 1

HCID 670364713-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione수율 40.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).

후처리

  1. customthe acetic acid was evaporated under reduced pressure
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-95faf5e1039043699af36e4b9bef83fc
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079904B2

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