Dissolve 3,4-dimethoxy-N—[(R)-1-(3-{(S)-6-[propyl-(2,2,2-trifluoro-acetyl)-amino]-4,5,6,7-tetrahydro-benzothiazol-2-ylcarbamoyl}-phenyl)-ethyl]-benzamide (109 mg, 0.18 mmol) into 10 mL of MeOH and add 5 mL of H2O. To this add K2CO3 (200 mg, 1.50 mmol) and heat the mixture overnight at 55° C. LC-MS analysis indicates the desired material. Add trifluoroacetic acid, dissolve into MeOH and purify via the Gilson Prep HPLC system (5%-70% CH3CN/H2O) to give 62.6 mg of the title compound. MS, electrospray 523.67 (M+H), rt 1.14 min.
