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2-[(4-Nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone → 2-[(4-Aminophenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone

HRID 15246
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HRID 15246 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([N:23]([CH3:25])[CH3:24])([CH2:21][CH3:22])[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])=[CH:6][CH:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([N:23]([CH3:25])[CH3:24])([CH2:21][CH3:22])[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])=[CH:6][CH:5]=1
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참가 물질

5

반응물 2

HCID 686377532-[(4-Nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanoneHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 686385232-[(4-Aminophenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

7.0 g Palladium on charcoal (5%) are added to solution of 69.5 g (0.178 mol) 2-[(4-nitro-phenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone in 700 ml ethanol in an hydrogenation autoclave. Hydrogen is entered with a continuous increase of pressure to 5 bar at temperature between room temperature and 40° C. After 25 hours no further hydrogen uptake is observed. The catalyst is filtered off and the crude product obtained as yellowish oil after evaporation of the solvent. Thin film chromatography shows a main product and some minor by-products. The crude material is used without further purification in the next reaction step.

후처리

  1. temperaturea continuous increase of pressure to 5 bar at temperature between room temperature and 40° C
  2. filtrationThe catalyst is filtered off

출처 및 근거

ORD 기록
ord-c0a59aec5c9b49048cc6d6e49041b7d0
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07732504B2

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