Methanol → Methyl 3-tert-butyl-5-hydroxybenzoate

HRID 1524606노트

반응식

HRID 1524606 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([OH:14])[CH:13]=1)[C:8]([OH:10])=[O:9])([CH3:4])([CH3:3])[CH3:2].S(Cl)(Cl)=O.[CH3:19]O>>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([OH:14])[CH:13]=1)[C:8]([O:10][CH3:19])=[O:9])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 217986673-t-Butyl-5-hydroxybenzoic acid

생성물 1

HCID 53399216Methyl 3-tert-butyl-5-hydroxybenzoate

실험 절차

3-tert-Butyl-5-hydroxybenzoic acid (O7.043; 1.93 g) was dissolved in methanol (20 ml), and thionyl chloride (0.937 ml) was slowly added dropwise while stirring. After stirring at 65° C. for 1 h, the mixture was dried, the residue was taken up in DCM, and the solution was washed with saturated sodium hydrogencarbonate solution, dried over MgSO4, filtered and concentrated by rotary evaporation. 2.19 g of the title compound were obtained.

후처리

  1. stirringAfter stirring at 65° C. for 1 h
  2. customthe mixture was dried
  3. washthe solution was washed with saturated sodium hydrogencarbonate solution
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated by rotary evaporation

출처 및 근거

ORD 기록
ord-4ef0304f7256444098cb49d8beb85e32
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079906B2

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