Ethanolamine → HCID 59341481, 화합물
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:21]([CH3:23])[CH3:22])([CH2:19][CH3:20])[C:10]([C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1.[CH2:24]([CH2:26][NH2:27])[OH:25]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:21]([CH3:23])[CH3:22])([CH2:19][CH3:20])[C:10]([C:12]2[CH:17]=[CH:16][C:15]([NH:27][CH2:26][CH2:24][OH:25])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1참가 물질
3
실험 절차
23.5 g (0.078 mol) 2-[(4-aminophenyl)methyl]-1-(4-fluorophenyl)-2-dimethylamino-1-butanone are reacted with ethanol amine (33.4 g, 0.55 mol) under conditions as described for example 1.2. The crude product obtained is purified by first by filtration over silica gel using hexane/ethyl acetate 1:1→ethyl acetate as the eluent, followed by flash chromatography on silica gel (eluant: ethyl acetate). 10.2 g (37%) 2-[(4-aminophenyl)methyl]-1-[4-(2-hydroxyethyamino)phenyl]-2-dimethylamino-1-butanone are obtained as a viscous yellow oil.
후처리
- customThe crude product obtained
- customis purified by
- filtration