1,4-Dioxane hydrochloride → Ethyl 4-((R)-amino(phenyl)methyl)phenyl(methyl)phosphinate hydrochloride
반응식
CC(C)([S@]([NH:6][C@H:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:8]1[CH:13]=[CH:12][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:10][CH:9]=1)=O)C.[ClH:27].O1CCOCC1>>[ClH:27].[NH2:6][C@H:7]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:8]1[CH:9]=[CH:10][C:11]([P:14]([CH3:19])(=[O:18])[O:15][CH2:16][CH3:17])=[CH:12][CH:13]=1참가 물질
3
실험 절차
Ethyl 4-((R)—((R)-1,1-dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate, 23-b, (9.5 g, 24.1 mmol) was dissolved in HCl/dioxane (100 ml) and the mixture was stirred at room temperature overnight. Then it was concentrated under vacuum and the residue was washed with ethyl acetate to provide the product, 23-c, (7.16 g, 91%).
후처리
- concentrationThen it was concentrated under vacuum