Potassium Hydroxide → HCID 178524763, 화합물
반응식
[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([O:16]CC)=[O:15])=[CH:9][N:8]=2)[CH:6]=1.[OH-].[K+]>CCO.O>[F:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[C:11]([OH:13])[C:10]([C:14]([OH:16])=[O:15])=[CH:9][N:8]=2)[CH:6]=1참가 물질
5
반응 조건
- 온도
- 78 °C
실험 절차
Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxylate, 28-f, (1 g, 3.9 mmol) was dissolved in EtOH (7 mL) and KOH (0.67 g, 11.9 mmol) in H2O (3 mL) was added. The mixture was stirred at 78° C. for 1.5 h. Then the solvent was evaporated, and the residue was added about 10 mL of H2O and filtered. The solid was dried and washed by EtOH (5 mL) to give the title product, 28-g, (0.7 g).
후처리
- customThen the solvent was evaporated
- additionthe residue was added about 10 mL of H2O
- filtrationfiltered
- customThe solid was dried
- washwashed by EtOH (5 mL)
출처 및 근거
- ORD 기록
- ord-abf3df972ba24d85b74d26bf5cf05d34
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09079930B2
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