Dichloromethane → HCID 131733156, 화합물

HRID 1525795노트

반응식

HRID 1525795 반응식
[CH2:1]([C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[C:23](=[O:26])([O-])[O-:24].[K+].[K+].Cl[CH2:30]Cl>ClC(OC)=O.O>[CH3:30][O:24][C:23](=[O:26])[NH:20][C:19]1[CH:18]=[CH:17][C:16]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:22][CH:21]=1

참가 물질

6

반응물 3

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 713745384-Pentadecylaniline

생성물 1

HCID 131733156HCID 131733156, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 6586Methyl chloroformate용매

실험 절차

To the solution of 4-pentadecanylaniline (3.4 g) in dichloromethane (60 mL), methyl chloroformate (1.1 mL) and the solution of potassium carbonate (7.8 g) in water (110 mL) were added at 0° C., followed by stirring at room temperature for 14 hours. The reaction solution was poured to water, followed by extraction with dichloroethane. The organic layer was washed sequentially with 2N hydrochloric acid, water and an aqueous saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. The reaction solution was concentrated under reduced pressure to obtain the title compound (3.9 g) having the following physical property values.

후처리

  1. extractionfollowed by extraction with dichloroethane
  2. washThe organic layer was washed sequentially with 2N hydrochloric acid, water
  3. dry with materialan aqueous saturated sodium chloride solution, and dried with anhydrous magnesium sulfate
  4. concentrationThe reaction solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-13fd395f19c3494abcaa9807e6014fc5
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085523B2

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