Thionyl Chloride → N-(2-chloroethyl)-N-methyl-octadecyl ammonium chloride

HRID 1525804노트

반응식

HRID 1525804 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][N:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:9]>ClCCCl>[Cl-:3].[Cl:3][CH2:6][CH2:7][NH+:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:9]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 13564486N-(2-hydroxyethyl)-N-methyl-octadecylamine

생성물 1

HCID 86722748N-(2-chloroethyl)-N-methyl-octadecyl ammonium chloride

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매2회

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온도
50 °C

실험 절차

Thionyl chloride (0.45 mL) was dissolved in 1,2-dichloroethane (3.0 mL). The solution of N-(2-hydroxyethyl)-N-methyl-octadecylamine (1.0 g) in 1,2-dichloroethane (7.0 mL) was added thereto at 0° C., followed by stirring at 50° C. for 30 minutes. The reaction solution was concentrated under reduced pressure and azeotrope was carried out with toluene twice to obtain the title compound (1.2 g) having the following physical property values.

후처리

  1. customat 0° C.
  2. concentrationThe reaction solution was concentrated under reduced pressure and azeotrope

출처 및 근거

ORD 기록
ord-ea442a2ce6364d72b993fe7baaff4c19
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085523B2

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