Hydrochloride methanol → 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

HRID 1525811노트

반응식

HRID 1525811 반응식
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:2].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:35](=[O:36])[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:28]2=[O:37])[C:21]1=[O:38].[ClH:39].CO>C(Cl)Cl>[ClH:39].[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]([NH:7][C@@H:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])=[O:6])[CH3:16].[OH:17][CH2:18][CH2:19][N:20]1[C:25](=[O:26])[CH2:24][CH2:23][CH:22]([N:27]2[C:28](=[O:37])[C:29]3[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:35]2=[O:36])[C:21]1=[O:38]

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 710827862-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate

생성물 1

HCID 866187522-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(2-diethylaminoacetamido)-3-methylbutanoate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound (76 mg) obtained from example 6 was dissolved in DCM (10 mL) and 15% HCl/methanol solution (5 mL) were added dropwise. The solvent was eliminated by rotary evaporation in vacuo and then white solid (82 mg) was obtained.

후처리

  1. customThe solvent was eliminated by rotary evaporation in vacuo

출처 및 근거

ORD 기록
ord-45671870be1d4665bec8b305410ff9c0
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085563B2

반응 노트

불러오는 중…