Hydrochloride methanol → 2-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

HRID 1525814노트

반응식

HRID 1525814 반응식
[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:28](=[O:29])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]2=[O:30])[C:14]1=[O:31].[ClH:32].CO>C(Cl)Cl>[ClH:32].[CH2:1]([N:3]([CH2:8][CH3:9])[CH2:4][C:5]([OH:7])=[O:6])[CH3:2].[OH:10][CH2:11][CH2:12][N:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH:15]([N:20]2[C:21](=[O:30])[C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:28]2=[O:29])[C:14]1=[O:31]

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 692485852-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate

생성물 1

HCID 692459092-(1-(2-Hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione 2-(diethylamino)acetate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound obtained from example 9 (76 mg) was dissolved in DCM (10 mL), and 15% HCl/methanol solution (10 mL) was added dropwise. The solvent was removed by rotary evaporation in vacuo to afford white solid (80 mg). Solubility of this compound in water was higher than 100 mg/mL.

후처리

  1. customThe solvent was removed by rotary evaporation in vacuo

출처 및 근거

ORD 기록
ord-7a028a4405a24593b8af150839450088
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085563B2

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