HCID 68484162, 화합물 → HCID 59733160, 화합물
반응식
C(OC(=O)[NH:10][C@@H:11]([CH3:25])[CH2:12][NH:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1)C1C=CC=CC=1>C(O)C.[Pd]>[F:22][C:21]([F:23])([F:24])[O:20][C:17]1[CH:16]=[CH:15][C:14]([NH:13][CH2:12][C@@H:11]([NH2:10])[CH3:25])=[CH:19][CH:18]=1참가 물질
4
실험 절차
[1-(S)-Methyl-2-(4-trifluoromethoxy-phenylamino)-ethyl]-carbamic acid benzyl ester (23.9 mmol) was dissolved in ethanol (200 mL) then placed under nitrogen. 10% Palladium on carbon was added (0.5 g) and the mixture was stirred under hydrogen (atmospheric pressure) overnight. When reaction was complete, the mixture was filtered through celite. The celite was washed with ethanol (5×50 ml) then evaporated in vacuo to give a brown oil (4.03 g, 17.21 mmol, 72% yield over 3 steps).
후처리
- customWhen reaction
- filtrationthe mixture was filtered through celite
- washThe celite was washed with ethanol (5×50 ml)
- customthen evaporated in vacuo
- customto give a brown oil (4.03 g, 17.21 mmol, 72% yield over 3 steps)
출처 및 근거
- ORD 기록
- ord-96ab33466ef34704abd36c0958727763
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732449B2
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