tert-butyl 5-nitro-1H-pyrazol-3-ylcarbamate → tert-butyl N-(5-amino-1H-pyrazol-3-yl)carbamate
반응식
[N+:1]([C:4]1[NH:8][N:7]=[C:6]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:5]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[NH:8][N:7]=[C:6]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:14])([CH3:13])[CH3:15])[CH:5]=1참가 물질
4
실험 절차
600 mg (10%) palladium on carbon is added under inert atmosphere to 5.88 g (25.77 mmol) of tert-butyl 5-nitro-1H-pyrazol-3-ylcarbamate diluted in 145 ml of methanol and then the reaction mixture is stirred under hydrogen atmosphere for 24 hours. The solution is filtered on Celite and then rinsed with ethyl acetate. The filtrate is concentrated to yield 4.93 g (96%) of tert-butyl 5-amino-1H-pyrazol-3-ylcarbamate in the form of a gray solid.
후처리
- filtrationThe solution is filtered on Celite
- washrinsed with ethyl acetate
- concentrationThe filtrate is concentrated
출처 및 근거
- ORD 기록
- ord-ab1d4f2a85984f52b356a052af06653e
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09085575B2
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