Cesium carbonate → 5-(2-methoxyethoxy)-1H-indole

HRID 1527183

반응식

HRID 1527183 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:17][O:18][CH2:19][CH2:20]Br>CC(C)=O>[CH3:17][O:18][CH2:19][CH2:20][O:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 160545-HydroxyindoleHCID 809722-Bromoethyl methyl ether

생성물 1

HCID 103525375-(2-methoxyethoxy)-1H-indole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

5-hydroxyindole (5 g, 15 mmol) was dissolved in acetone (75 mL), cesium carbonate (5.38 g, 16.5 mmol) and 2-bromoethyl methyl ether (1.55 mL, 16.5 mmol) were added and the reaction mixture was stirred at reflux under nitrogen overnight. Acetone was concentrated. The residue was dissolved in water and extracted twice with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated. The crude residue was purified by flash column chromatography on silica gel (c-hexane to c-hexane/EtOAc 7/3) to give the desired material. TLC, Rf (c-hexane/EtOAc 1:1)=0.6; MS (LC-MS): 192.1 [M+H]+, 214.0 [M+Na]+, 405.1 [2M+Na]+; tR (HPLC conditions f): 1.56 min.

후처리

  1. temperatureat reflux under nitrogen overnight
  2. concentrationAcetone was concentrated
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted twice with EtOAc
  5. dry with materialThe combined organic layers were dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe crude residue was purified by flash column chromatography on silica gel (c-hexane to c-hexane/EtOAc 7/3)

출처 및 근거

ORD 기록
ord-71222328413d4a1e9da2c81a9008df67
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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