Trifluoroacetic acid → HCID 68284012, 화합물
반응식
C([O:5][C:6](=[O:20])[CH2:7][N:8]1[C:12]2[N:13]=[CH:14][N:15]=[CH:16][C:11]=2[C:10]([C:17](=[O:19])[CH3:18])=[CH:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:17]([C:10]1[C:11]2[CH:16]=[N:15][CH:14]=[N:13][C:12]=2[N:8]([CH2:7][C:6]([OH:20])=[O:5])[CH:9]=1)(=[O:19])[CH3:18]참가 물질
4
실험 절차
A solution of (5-acetyl-pyrrolo[2,3-d]pyrimidin-7-yl)-acetic acid tert-butyl ester (146 mg, 0.53 mmol) and TFA (0.814 mL, 10.62 mmol) in CH2Cl2 (2.5 mL) was stirred at RT for 24 h. Solvents were removed under reduced pressure and the material thus obtained was used without further purification in the next step. 1H-NMR (400 MHz, DMSO): δ (ppm): 9.45 (s, 1H), 9.0 (s, 1H), 8.68 (s, 1H), 7.66-7.56 (m, 2H), 5.16 (s, 2H), 2.53 (s, 3H).
후처리
- customSolvents were removed under reduced pressure
- customthe material thus obtained
- customwas used without further purification in the next step
출처 및 근거
- ORD 기록
- ord-08496146c2534a20bda64b0f1f208b9f
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09085555B2
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