Trifluoroacetic acid → (3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

HRID 1527272노트

반응식

HRID 1527272 반응식
C([O:5][C:6](=[O:21])[CH2:7][N:8]1[C:12]2=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=[C:11]2[C:10]([C:18](=[O:20])[CH3:19])=[N:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:18]([C:10]1[C:11]2[C:12](=[CH:13][N:14]=[C:15]([CH3:17])[CH:16]=2)[N:8]([CH2:7][C:6]([OH:21])=[O:5])[N:9]=1)(=[O:20])[CH3:19]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68283035(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester

생성물 1

HCID 68283539(3-Acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of (3-acetyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid tert-butyl ester (126 mg, 0.37 mmol) and TFA (0.171 mL, 2.22 mmol) in CH2Cl2 (5 mL) was stirred at RT for 24 h. Solvents were removed under reduced pressure, Et2O was added and the precipitate was filtered, washed with Et2O and dried under high vacuum. The material thus obtained was used without further purification in the next step. MS (UPLC/MS): 234 [M+H]+, 232 [M−H]−, 465 [2M−H]−; tR (HPLC conditions f): 0.53 min.

후처리

  1. customSolvents were removed under reduced pressure, Et2O
  2. additionwas added
  3. filtrationthe precipitate was filtered
  4. washwashed with Et2O
  5. customdried under high vacuum
  6. customThe material thus obtained
  7. customwas used without further purification in the next step
  8. custom0.53 min.

출처 및 근거

ORD 기록
ord-51abe66e203b461bbaac33338cfa7462
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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