Trifluoroacetic acid → (2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

HRID 1527382노트

반응식

HRID 1527382 반응식
C(OC([N:8]1[CH2:12][C@H:11]([F:13])[CH2:10][C@H:9]1[CH2:14][N:15]=[N+:16]=[N-:17])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:15]([CH2:14][C@@H:9]1[CH2:10][C@@H:11]([F:13])[CH2:12][NH:8]1)=[N+:16]=[N-:17]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86673832HCID 86673832, 화합물

생성물 1

HCID 86673833(2S,4R)-2-Azidomethyl-4-fluoro-pyrrolidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2S,4R)-2-azidomethyl-4-fluoro-pyrrolidine-1-carboxylic acid tert-butyl ester (600 mg, 2.45 mmol) in CH2Cl2 (2.5 mL) was added TFA (1.88 mL, 24.6 mmol) and the solution was stirred at RT for 2 h. CH2Cl2 was concentrated and the crude was dried under high vacuum to give the desired material which was used without further purification in the next step.

후처리

  1. concentrationCH2Cl2 was concentrated
  2. customthe crude was dried under high vacuum

출처 및 근거

ORD 기록
ord-68646736dd584fda86226b06b63909c7
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

반응 노트

불러오는 중…