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(2-Chloro-3-Fluoropyridin-4-Yl)Methanol → 2-Chloro-3-fluoro-4-formylpyridine

HRID 1527463
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HRID 1527463 반응식
[Cl:1][C:2]1[C:7]([F:8])=[C:6]([CH2:9][OH:10])[CH:5]=[CH:4][N:3]=1>C(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1
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참가 물질

4

반응물 1

HCID 54759140(2-Chloro-3-Fluoropyridin-4-Yl)Methanol

생성물 1

HCID 27631602-Chloro-3-fluoro-4-formylpyridine

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (2-chloro-3-fluoro-pyridin-4-yl)-methanol (0.9 g, 5.76 mmol) and activated MnO2 (5.76 g, 66.2 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off and washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a colorless liquid. MS (LC/MS): 191.0 [M+MeOH]+; tR (HPLC conditions b): 2.02 min.

후처리

  1. filtrationThe solid was filtered off
  2. washwashed with CH2Cl2
  3. concentrationthe filtrate was concentrated under mildly reduced pressure

출처 및 근거

ORD 기록
ord-34c2d5f4d1b641f8a7b5b970503f2173
출처 데이터셋
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09085555B2

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