[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol → 3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

HRID 1527467노트

반응식

HRID 1527467 반응식
[F:1][C:2]1[C:3]([C:10]([F:13])([F:12])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][OH:9]>C(Cl)Cl.O=[Mn]=O>[F:1][C:2]1[C:3]([C:10]([F:12])([F:13])[F:11])=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9]

참가 물질

4

반응물 1

HCID 68283421[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol

생성물 1

HCID 866738643-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of (3-fluoro-2-trifluoromethyl-pyridin-4-yl)-methanol (0.620 g, 3.18 mmol) and activated MnO2 (3.20 g, 36.5 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off, washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a yellow liquid. MS (LC/MS): 212.0 [M+NH4]+, 226.0 [M+MeOH]+. tR (HPLC conditions c): 3.26 min.

후처리

  1. filtrationThe solid was filtered off
  2. washwashed with CH2Cl2
  3. concentrationthe filtrate was concentrated under mildly reduced pressure

출처 및 근거

ORD 기록
ord-8b86983cf75a440fb942803377df3f4b
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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