Trifluoroacetic acid → 3-Aminomethyl-5-chloro-4-fluoro-N-methyl-benzamide

HRID 1527504노트

반응식

HRID 1527504 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15](=[O:18])[NH:16][CH3:17])[CH:12]=[C:11]([Cl:19])[C:10]=1[F:20])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:12]=[C:11]([Cl:19])[C:10]=1[F:20])[C:15]([NH:16][CH3:17])=[O:18]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68283777(3-Chloro-2-fluoro-5-methylcarbamoyl-benzyl)-carbamic acid tert-butyl ester

생성물 1

HCID 682845193-Aminomethyl-5-chloro-4-fluoro-N-methyl-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

was prepared according to Scheme C3 (step B) from (3-chloro-2-fluoro-5-methylcarbamoyl-benzyl)-carbamic acid tert-butyl ester (99 mg, 0.3 mmol) and TFA (0.5 mL) in CH2Cl2. MS (LC-MS): 217.0 [M]+; tR (HPLC conditions c): 2.39 min.

후처리

  1. customwas prepared
  2. custom2.39 min.

출처 및 근거

ORD 기록
ord-ad51c25bea264edaa07f8f6ddac7df1d
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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